Peptidyss® - Marine Peptides with Proven Effectiveness in Stress and Sleep Management

1. Understanding Stress and Sleep Challenges in Modern Life

1.1 The Prevalence of Stress and Its Impact

Stress is a ubiquitous challenge in today’s fast-paced world. The Ifop for Mes Bienfaits survey (2022) revealed that 79% of respondents frequently experienced stress, citing factors like workload, financial pressure, and digital overstimulation. This chronic stress not only hampers mental well-being but manifests physically, contributing to headaches, hypertension, and weakened immunity.

Moreover, findings from the FMCG Gurus’ 2021 report highlight that 46% of global consumers actively seek products to reduce stress. Stress alters hormone levels, including cortisol, and disrupts the brain's balance, particularly in regions controlling emotional regulation. If unaddressed, these imbalances can spiral into anxiety, depression, and lifestyle-related illnesses.

1.2 Sleep Disorders: A Rising Concern

Sleep and stress are intrinsically linked. Chronic stress disrupts sleep by overstimulating the hypothalamic-pituitary-adrenal (HPA) axis, which regulates the body's stress response. The FMCG Gurus’ report also underscores that nearly 63% of global consumers reported worsening sleep quality in the past year, citing stress as the primary culprit. Poor sleep exacerbates fatigue, irritability, and cognitive decline, creating a vicious cycle of stress and insomnia.

Despite the growing awareness of this relationship, few solutions comprehensively address both conditions simultaneously. This presents a compelling opportunity for innovative interventions like Peptidyss®, which target stress and sleep management holistically.

2.  Peptidyss®: The Natural and Effective Solution

Peptidyss® is a natural marine peptide derived from the enzymatic hydrolysis of fish proteins (Proteins: ≥70%; Minerals:  ≤ 20%). Naturally occurring in marine ecosystems, these peptides exhibit multifunctional properties, including antioxidative, anti-inflammatory, and neuroprotective effects. Their low molecular weight (<3000 Da), enables rapid absorption, ensuring high bioavailability and efficacy in addressing health issues.

Unlike synthetic pharmaceuticals, Peptidyss® offers a natural alternative that aligns with the clean-label trend. Their unique amino acid sequences interact with key biological pathways, regulating stress responses and improving metabolic functions. This makes them a promising ingredient for stress and sleep management products.

3. Peptidyss®: Scientific Evidence and Benefits

Recent advancements in peptide research have revealed the potential of marine-derived compounds in tackling modern health challenges. Preclinical and clinical studies demonstrate their efficacy in modulating the HPA axis, reducing oxidative stress, and enhancing neuronal communication. Molecular research has also uncovered their ability to influence gene expression related to mood regulation and circadian rhythms.

3.1 Anti-Stress Benefits of Peptidyss®

The clinical study Julie Le Faouder et al. (2022)⁽¹⁾, highlights Peptidyss®’s capacity to counteract stress at a molecular level. In this study, researchers used quantitative proteomics to analyze changes in hippocampal proteins in mice supplemented with Peptidyss® (300 mg/kg body weight) over seven days and subjected to mild acute stress. Administering fish hydrolysates (300 mg/kg body weight) to stressed mice over seven days demonstrated significant modulation of hippocampal proteins related to mitochondrial function and neuronal health.

Key findings include:

• Anti-stress activity comparable to a benzodiazepine, without side effects.
• Regulation of stress hormone secretion, helping to prevent negative long-term effects such as sleep disorders, irritability, or hypertension.
• Modulation of gene and protein expression involved in stress management, circadian rhythm, and the aging process.

These findings suggest that Peptidyss® may help counteract the biological impacts of stress, offering a promising natural strategy for stress management.

3.2 Sleep-Enhancing Properties of Peptidyss®

The study Franziska Eckert et al (2024)⁽²⁾ provides compelling evidence of Peptidyss®’s role in sleep improvement. The double-blind, placebo-controlled trial reported significant enhancements in sleep quality, efficiency, and reduced disturbances among participants.

Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), an online diary, and a wrist wearable device. Additionally, questionnaires related to stress, anxiety, depression, and well-being were evaluated and salivary cortisol and product satisfaction were assessed.

Highlights include:

• Improvement of sleep quality by 15%.
• Improvement of sleep efficacy for 55% of participants.
• Reduction of daytime sleepiness for 71% of participants.
• Improvement of physical health for 71% of participants.

The findings suggest that Peptidyss® is a safe and promising supplement for individuals with self-reported sleep issues, although further research is needed to confirm its efficacy compared to placebo.

4. Applications in Food, Dietary Supplements, and Nutricosmetics

4.1 Versatile Uses Across Industries

Peptidyss® offers various applications across the food, dietary supplement, and nutricosmetic sectors. Its compatibility with functional foods makes it an ideal addition to beverages, protein bars, and fortified snacks. In dietary supplements, it addresses consumer needs for stress relief and sleep enhancement without artificial additives.

In nutricosmetics, marine peptides’ antioxidant properties contribute to skin health, making Peptidyss® a valuable ingredient for beauty-from-within products. Its versatility aligns with the clean-label demand, enhancing product formulations across industries.

5. Why Choose Peptidyss®?

Peptidyss® is not just an ingredient but a comprehensive solution for stress and sleep-related issues. Its benefits include:

• Science back-up: Clinical, transcriptomic, proteomic studies, peer validation.
• Unique & natural composition: Rich in low molecular weight peptides, which makes it highly digestible and bioavailable.
• Low Dosage: Only 300mg/day.
• Clean Label: Free from synthetic additives or chemicals.
• Sustainability: Local by-products valorization, eco-responsible process, solvent and preservative-free.
• Versatile Applications: Suitable for various industries, from food and dietary supplements to nutricosmetics.

With a strong scientific foundation, natural origin, and ability to address common issues like stress and sleep, Peptidyss® is a groundbreaking choice. It is not just a raw ingredient but also a tool to create health-supporting products that enhance consumers' quality of life.

(1) Julie Le Faouder et al. Fish Hydrolysate Supplementation Prevents Stress-Induced Dysregulation of Hippocampal Proteins Relative to Mitochondrial Metabolism and the Neuronal Network in Mice. Foods 2022, 11, 1591.

(2) Franziska Eckert et al.Efficacy of a fish hydrolysate supplement on sleep quality: A randomized, double-blind, placebo-controlled, crossover clinical trial.  Clinical Nutrition ESPEN 60 (2024) 48-58.