The Growing Focus on Joint Health in the Market

Joint health has rapidly gained prominence in the dietary supplement and nutraceutical sectors. With aging populations and increasing awareness of proactive health measures, consumers now prioritize long-term mobility and quality of life. A shift in preferences toward plant-based, sustainable solutions has further fueled innovation in joint health products. While traditional glucosamine and chondroitin supplements still dominate, the market is now seeing a surge in natural alternatives, driven by their broad appeal and lower risk of side effects.

The Role of Mangosteen in Joint Health

Mangosteen, often referred to as the "queen of fruits," has long been revered in traditional medicine for its potent anti-inflammatory and antioxidant properties. Its rich concentration of bioactive compounds, particularly xanthones, makes it uniquely suited for addressing joint discomfort. Unlike conventional treatments that focus solely on symptom management, mangosteen targets underlying mechanisms such as inflammation and oxidative stress, providing a more holistic approach to joint health.

Mangoselect®: A Proactive Approach to Joint Health

1. Key Features of Mangoselect®

Mangoselect® is a proprietary extract derived from the pericarp (rind) of the mangosteen fruit. Unlike generic mangosteen extracts, Mangoselect® is produced using advanced extraction techniques that preserve and concentrate its bioactive compounds, particularly alpha- and gamma-mangostins (α-mangostin    ≥ 10%,   γ-mangostin    ≥ 1%) helping: 

• Alleviate joint discomfort associated with inflammation
• Clinically proven to be effective in 5 days of supplementation
• Suitable for both athlete's population and elders

Besides, mangoselect® is designed with the end-user in mind. It is non-GMO, allergen-free, and compatible with various dietary preferences, including vegan and vegetarian lifestyles. This ensures it meets the broad spectrum of consumer needs in today’s global marketplace.

2. Science Supporting Mangoselect®

Mechanism of Action

Mangoselect® works at the cellular level, targeting key pathways associated with joint health. Its xanthones inhibit pro-inflammatory cytokines, reducing joint inflammation and associated pain. Additionally, its antioxidant activity combats oxidative stress, a significant contributor to cartilage degradation and joint stiffness. By addressing these root causes, Mangoselect® supports long-term joint functionality and mobility.

Clinically Supported Benefits

A mechanistic study confirmed the action of Mangoselect® by inducing systemic inflammation with intraperitoneal LPS (lipopolysaccharides) injections then measuring the blood levels of primary inflammatory mediator, TNF-α (tumor necrosis factor alpha). 90 minutes after the injection of LPS, the Mangoselect® group showed significantly lower levels of TNF-α.

Double-blind, randomised, placebo-controlled clinical study including 24 subjects (9 elderly people with joint pain due to old age, 15 athletes with joint pain due to exercise) have validated Mangoselect®’s efficacy in improving joint comfort and mobility. Mangoselect® has been demonstrated to be effective at significantly reducing joint discomfort in both groups within 5 days with dosage of 2 x 300 mg/day:

• ​Chronic condition (older people): discomfort is significantly reduced by 50%.​
• Acute condition (athletes): discomfort is significantly reduced by 31%.​

These findings and its excellent safety profile position Mangoselect® as a reliable option for individuals seeking natural joint health solutions.

4. Applications of Mangoselect® in the Dietary Supplement Market

Mangoselect®’s water-soluble and oil-soluble forms allow seamless integration into diverse product formats. From traditional capsules and tablets to innovative functional beverages and gummies, Mangoselect® caters to evolving consumer preferences for convenient and enjoyable supplement options.

Besides, currently, bone and joint products from Glucosamine, chondroitin, frankincense and especially bone and joint support products from Eastern medicine and Southern remedies such as "Doc Hoat Tang Parasitic" often have some disadvantages such as:

• The pain relief effect appears quite late => affecting the customer's experience of using the product + patients often have to combine it with anti-inflammatory pain relievers from Western Medicine.
• Pain relief effectiveness depends largely on the patient's condition, type of disease and stage of the disease => treatment response rate is not high.
• The pain relief effect is not high => patients with acute pain or severe degenerative conditions will be less effective.

Mangoselect® can be used separately or in combination to improve products, increase treatment effectiveness, and create natural, fast-acting and safe pain relief products specifically for diseases related to bone and joint diseases.