Gastro-AD®: Breakthrough solution from Postbiotic for gastric reflux

1. A Heartburn And Acid Reflux

Heartburn and acid reflux are more than occasional discomforts—they’re indicators of a deeper, systemic issue tied to modern diets, lifestyle stressors, and microbiome imbalances. Despite affecting up to 20% of the global population, solutions remain reactive, often failing to address root causes. While most discussions focus on short-term pH neutralization, few experts acknowledge the immune component of gastric inflammation or the role of microbial metabolites in long-term digestive resilience.

Synthetic treatments like proton pump inhibitors (PPIs) or H2 blockers have long dominated the market. However, these come with significant downsides: reduced nutrient absorption, microbiome disruption, and rebound hyperacidity. On the other hand, natural alternatives are often dismissed due to lack of scientific rigor.

What’s frequently overlooked is the possibility of combining the best of both worlds: a naturally derived, science-backed ingredient that addresses not only the acid itself but also the inflammatory and immune responses that aggravate and perpetuate symptoms.

This is where Gastro-AD®, a fermented soy-based ingredient by Lallemand, emerges as a game-changer. Rooted in decades of research and now validated through modern clinical trials, Gastro-AD® challenges conventional thinking by offering triple-action relief—buffering acid, regulating gastric secretions, and enhancing mucosal immunity—without pharmaceutical side effects.

2. Gastro-AD®: Postbiotic Solution For Stomach Health

Gastro-AD® is not just another fermented food supplement; it is a biotechnological innovation derived from non-GMO soy flour, fermented with a specific, highly studied strain—Lactobacillus delbrueckii Rosell-187 (an unique Lactobacillus strain of Lallemand). This fermentation process doesn't just preserve the soy—it transforms it, creating bioactive compounds that conventional soy products lack.

Rosell-187 is a proprietary, high-performing lactic acid bacteria (LAB) known for its ability to modulate immune signaling pathways. Unlike general probiotic strains, Rosell-187 stimulates interleukin-6 (IL-6), which promotes antibody production, while suppressing pro-inflammatory IL-8—directly benefiting the stomach’s mucosal lining. The presence of peptides like lunasin and genistein, derived from fermented soy, adds a powerful anti-inflammatory and antioxidant profile.

Few in the industry discuss the implications of this kind of fermentation. Traditional probiotics often die in the acidic gastric environment, but Gastro-AD® utilizes even inactivated bacterial components to trigger a beneficial immune cascade. This breaks the mold of relying on live microbes, opening a new avenue for postbiotic therapy—a hot, yet underexplored, topic in digestive health.

These properties allow Gastro-AD® to serve as both a preventive and reactive solution, addressing not only the symptomatic relief of heartburn but also chronic conditions like gastritis and duodenal ulcers. With over 700 patients evaluated across multiple trials, Gastro-AD®’s effectiveness is well-documented, yet its depth of action remains surprisingly underappreciated in mainstream nutraceutical discussions.

3. Mechanisms Beyond Neutralization

One of the most compelling aspects of Gastro-AD® is its multi-mechanistic approach. While most remedies focus on neutralizing or suppressing stomach acid, Gastro-AD® employs three synergistic pathways to bring fast and lasting relief:

1. Acid Buffering 

Gastro-AD® contains naturally occurring peptides from soy fermentation that act as mild buffers. Unlike synthetic antacids, these peptides don't overstimulate the stomach to compensate for pH changes. Instead, they gently normalize the stomach’s environment, providing immediate relief while supporting long-term balance.

2. Suppression of Gastric Acid Secretion

Studies (e.g., Lee 2022) have shown that Gastro-AD® reduces acid output even in stress-induced models. This is especially important for individuals suffering from alcohol-induced or food-triggered reflux, where acid suppression can prevent tissue damage. Formate—a fermentation by-product—plays a key role in downregulating gastric fluid secretion, a nuance rarely discussed in overviews of natural reflux remedies.

3. Beneficial Effect on the Immune System

Rosell-187 suppresses inflammatory responses by inhibiting IL-8 and enhances immunity by stimulating IL-6 production, helping to reduce inflammation and rapidly heal the gastric mucosa, thereby providing long-term stomach protection even after discontinuation of use.

Through immunomodulatory compounds such as lunasin and genistein, Gastro-AD® supports a healthier mucosal lining, less prone to damage or ulceration. This mechanism is unique to postbiotic products and unmatched by current over-the-counter options, which often overlook the inflammatory component of chronic gastric issues.

Together, these mechanisms allow Gastro-AD® to function not merely as a symptom mask but as a therapeutic ally in restoring gastrointestinal homeostasis—a topic underrepresented in discussions of heartburn supplements.

4. Clinical Evidence of Gastro-AD®

While the market is saturated with anecdotal claims and unverified herbal blends, Gastro-AD® stands out with decades of clinical data. From early trials in the 1970s by Dr. Bogdanov to recent double-blind placebo-controlled studies, the efficacy of this fermented soy formula is well-established.

In one 2020 study published in BMC Research Notes, participants receiving 1g of Gastro-AD® daily showed a 56% reduction in heartburn episodes over the treatment period. Remarkably, symptom relief persisted even during the washout phase, indicating a cumulative or restorative effect on gut health. Another study from Korea demonstrated significant improvements in quality of life metrics, including sleep quality, appetite, and mental clarity—areas often neglected in GERD research.

Moreover, trials show Gastro-AD®’s benefits are not limited to symptomatic individuals. Even those with mild gastric discomfort or stress-induced dyspepsia reported better digestion, less bloating, and improved post-meal comfort. This positions Gastro-AD® as not only a treatment but a daily wellness enhancer, particularly useful for at-risk populations such as older adults, frequent travelers, and individuals with irregular eating habits.

In contrast to standard natural supplements, few of which have undergone rigorous evaluation, Gastro-AD®’s clinical profile bridges the credibility gap between nutraceuticals and pharmaceuticals—a distinction that few ingredients can truly claim.

5. Finished Product Innovation and Market Differentiation

Developed by Lallemand—a global leader with decades of experience in fermentation and microbiology—Gastro-AD® is backed by solid scientific foundations and a rigorous quality control system.

• It is formulated using a proprietary strain of Lactobacillus delbrueckii and non-GMO soybeans.
• No solvents or chemical additives are used during the fermentation process.
• The product results from a long-term research journey that began in the 1950s, with over 700 participants involved in clinical studies.
• Gastro-AD® is 100% natural, safe, and free of side effects, with proven scientific efficacy, making it a viable alternative to over-the-counter (OTC) treatments.

It has been incorporated into various finished product formats, including chewable tablets, capsules, powder sachets, gel sticks, gummies, and ready-to-drink bottles. This versatility in dosage forms makes Gastro-AD® highly adaptable for different consumer groups and allows it to be used in both clinical settings and daily wellness routines.

Notably, Gastro-AD® can also be combined with hangover support products, helping protect the gastric lining from ethanol-induced damage and adding extra value for health-conscious modern consumers.